PF3D7_0815500

Genome location: Pf3D7_08_v3:727,118..730,725(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	expressed	0.74	0.65
Schizont	expressed	0.59	0.71
Gametocyte	not expressed	0.28	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0815500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.344 | MFS: -2.692 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAZ2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533653

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	17	11	31
disruptive	11	38	20	80
missense	9	34	18	70

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	35	18	32
disruptive	19	102	51	98
missense	11	84	45	69

PlasmoDB Total SNPs: 141

Non-coding: 116 | Synonymous: 14 | Nonsynonymous: 9 | Stop Codon: 2

Protein Information

Protein Length: 491 | Molecular Weight (kDa): 58.164

UniProt ID(s): Q8IAZ2

PDB ID(s): None

Isoelectric Point: 6.29

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A