Product Description: eukaryotic translation initiation factor 3 subunit G, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0003729 | mRNA binding |
| Function | GO:0003743 | translation initiation factor activity |
| Process | GO:0006412 | translation |
| Process | GO:0006413 | translational initiation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 1.06 | 0.53 |
| Trophozoite | expressed | 0.96 | 0.50 |
| Schizont | possibly expressed | 0.20 | 0.88 |
| Gametocyte | not expressed | 0.87 | 0.54 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0815600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.466 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IAZ3
"Best" AlphaFill ligand hit: C8E ((hydroxyethyloxy)tri(ethyloxy)octane, Local RMSD=0.01) with 2X4M (Global RMSD=18.55)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102687
Most Similar Human Ortholog: K7EP16
TM-align score: 0.60 | RMSD: 1.95
Seq Identity: 0.50 | Length: 78 / 268
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000130811 | eukaryotic translation initiation factor 3 subunit G |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 12 | 6 | 17 |
| disruptive | 0 | 2 | 7 | 14 |
| missense | 0 | 2 | 7 | 12 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 24 | 12 | 19 |
| disruptive | 1 | 21 | 19 | 42 |
| missense | 0 | 12 | 16 | 30 |
PlasmoDB Total SNPs: 174
Non-coding: 166 | Synonymous: 8 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 268 | Molecular Weight (kDa): 31.251
UniProt ID(s): Q8IAZ3
PDB ID(s): None
Isoelectric Point: 6.52
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR017334 | Eukaryotic translation initiation factor 3 subunit G |
| InterPro | IPR024675 | Eukaryotic translation initiation factor 3 subunit G, N-terminal |
| InterPro | IPR034240 | eIF3G, RNA recognition motif |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| PFam | PF12353 | Eukaryotic translation initiation factor 3 subunit G, N-terminal |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 28728781 | A yeast two-hybrid assay reveals CMYA1 interacting proteins | Xin X, Wang T, ..., Guo H | 10.1016/j.crvi.2017.06.003 |