Product Description: ribosome assembly protein RRB1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005730 | nucleolus |
| Process | GO:0042254 | ribosome biogenesis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.48 | 0.77 |
| Trophozoite | expressed | 0.32 | 0.81 |
| Schizont | possibly expressed | 0.11 | 0.93 |
| Gametocyte | expressed | 0.27 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0816000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.126 | MFS: -2.843 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0714800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IAZ7
"Best" AlphaFill ligand hit: SIW (keggin (sta), Local RMSD=0.10) with 6Y7O (Global RMSD=2.27)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102504
Most Similar Human Ortholog: M0QX71
TM-align score: 0.81 | RMSD: 3.12
Seq Identity: 0.31 | Length: 215 / 491
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000105447 | glutamate rich WD repeat containing 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 23 | 15 | 34 |
| disruptive | 10 | 45 | 23 | 79 |
| missense | 6 | 41 | 22 | 74 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 52 | 24 | 30 |
| disruptive | 26 | 87 | 52 | 120 |
| missense | 14 | 78 | 46 | 97 |
PlasmoDB Total SNPs: 110
Non-coding: 75 | Synonymous: 24 | Nonsynonymous: 11 | Stop Codon: 0
Protein Length: 491 | Molecular Weight (kDa): 56.509
UniProt ID(s): Q8IAZ7
PDB ID(s): None
Isoelectric Point: 4.97
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR019775 | WD40 repeat, conserved site |
| InterPro | IPR022052 | Histone-binding protein RBBP4, N-terminal |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | PF00400 | WD40 repeat |
| PFam | PF12265 | Histone-binding protein RBBP4, N-terminal |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 15467761 | Inactivation of the RRB1-Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability | Killian A, Le Meur N, ..., Flaman JM | 10.1038/sj.onc.1207845 |
| 26112308 | Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones | Pausch P, Singh U, ..., Kressler D | 10.1038/ncomms8494 |
| 15885502 | The WD-repeat protein GRWD1: potential roles in myeloid differentiation and ribosome biogenesis | Gratenstein K, Heggestad AD, ..., Fletcher BS | 10.1016/j.ygeno.2005.02.010 |
| 11158312 | Rrb1p, a yeast nuclear WD-repeat protein involved in the regulation of ribosomebiosynthesis | Iouk TL, Aitchison JD, Maguire S, Wozniak RW | 10.1128/MCB.21.4.1260-1271.2001 |
| 11728313 | A yeast homolog of chromatin assembly factor 1 is involved in early ribosome assembly | Schaper S, Fromont-Racine M, ..., Yaniv M | 10.1016/s0960-9822(01)00584-x |