Product Description: phosphopantothenoylcysteine decarboxylase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 4.1.1.36 (Phosphopantothenoylcysteine decarboxylase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0071513 | phosphopantothenoylcysteine decarboxylase complex |
| Function | GO:0010181 | FMN binding |
| Function | GO:0004633 | phosphopantothenoylcysteine decarboxylase activity |
| Process | GO:0015937 | coenzyme A biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.77 | 0.65 |
| Trophozoite | possibly expressed | 0.25 | 0.86 |
| Schizont | expressed | 0.76 | 0.56 |
| Gametocyte | not expressed | 0.15 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0816100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.162 | MFS: -2.912 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0714700)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0714900)
Modification: Disrupted | RMgm-4183
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IAZ8
"Best" AlphaFill ligand hit: FMN (flavin mononucleotide, Local RMSD=0.91) with 6TGV (Global RMSD=1.28)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 4.1.1.36 | phosphopantothenoylcysteine decarboxylase | ATPUTPKCNNaBH4Diketenepyridoxaliodoacetamidehydroxylaminephenylhydrazine4'-phosphopantothenolpyridoxal 5'-phosphatepantotheine 4-phosphate... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100772
Most Similar Human Ortholog: Q96CD2
TM-align score: 0.93 | RMSD: 1.17
Seq Identity: 0.39 | Length: 180 / 185
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000138621 | phosphopantothenoylcysteine decarboxylase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 3 | 2 | 9 |
| disruptive | 2 | 9 | 6 | 14 |
| missense | 2 | 9 | 6 | 13 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 11 | 9 | 12 |
| disruptive | 2 | 19 | 14 | 27 |
| missense | 2 | 17 | 12 | 21 |
PlasmoDB Total SNPs: 134
Non-coding: 122 | Synonymous: 10 | Nonsynonymous: 1 | Stop Codon: 1
Protein Length: 185 | Molecular Weight (kDa): 21.402
UniProt ID(s): Q8IAZ8
PDB ID(s): None
Isoelectric Point: 5.29
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003382 | Flavoprotein |
| InterPro | IPR036551 | Flavin prenyltransferase-like |
| PFam | PF02441 | Flavoprotein |
| Superfamily | SSF52507 | Flavin prenyltransferase-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 26514574 | Complex stability and dynamic subunit interchange modulates the disparateactivities of the yeast moonlighting proteins Hal3 and Vhs3 | Abrie JA, Molero C, Arino J, Strauss E | 10.1038/srep15774 |
| 38012152 | Sis2 regulates yeast replicative lifespan in a dose-dependent manner | Olmez TT, Moreno DF, ..., Acar M | 10.1038/s41467-023-43233-y |
| 28676844 | Genetic Characterization of Coenzyme A Biosynthesis Reveals Essential DistinctiveFunctions during Malaria Parasite Development in Blood and Mosquito | Hart RJ, Abraham A, Aly ASI | 10.3389/fcimb.2017.00260 |
| 27855724 | Biological characterization of chemically diverse compounds targeting thePlasmodium falciparum coenzyme A synthesis pathway | Fletcher S, Lucantoni L, ..., Avery VM | 10.1186/s13071-016-1860-3 |