Product Description: vacuolar protein sorting-associated protein 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000815 | ESCRT III complex |
| Component | GO:0005771 | multivesicular body |
| Process | GO:0032509 | endosome transport via multivesicular body sorting pathway |
| Process | GO:0045324 | late endosome to vacuole transport |
| Process | GO:0015031 | protein transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 1.00 |
| Trophozoite | not expressed | 0.14 | 0.90 |
| Schizont | expressed | 0.16 | 0.89 |
| Gametocyte | expressed | 0.18 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0816200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.241 | MFS: -2.944 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IAZ9
"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=18.23) with 4DKJ (Global RMSD=26.44)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102450
Most Similar Human Ortholog: M0QXX8
TM-align score: 0.80 | RMSD: 1.51
Seq Identity: 0.42 | Length: 48 / 209
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000130724 | charged multivesicular body protein 2A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 11 | 5 | 5 |
| disruptive | 5 | 7 | 4 | 20 |
| missense | 5 | 7 | 4 | 19 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 14 | 3 | 13 |
| disruptive | 5 | 17 | 13 | 43 |
| missense | 5 | 13 | 12 | 35 |
PlasmoDB Total SNPs: 51
Non-coding: 41 | Synonymous: 8 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 209 | Molecular Weight (kDa): 24.828
UniProt ID(s): Q8IAZ9
PDB ID(s): None
Isoelectric Point: 8.88
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005024 | Snf7 family |
| PFam | PF03357 | Snf7 family |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 30506264 | Interactions in the ESCRT-III network of the yeast Saccharomyces cerevisiae | Brune T, Kunze-Schumacher H, Kolling R | 10.1007/s00294-018-0915-8 |
| 27075672 | Structural Fine-Tuning of MIT-Interacting Motif 2 (MIM2) and AllostericRegulation of ESCRT-III by Vps4 in Yeast | Kojima R, Obita T, Onoue K, Mizuguchi M | 10.1016/j.jmb.2016.04.007 |