Product Description: small heat shock protein HSP20, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0070258 | inner membrane pellicle complex |
| Function | GO:0043621 | protein self-association |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0051259 | protein complex oligomerization |
| Process | GO:0006457 | protein folding |
| Process | GO:0009408 | response to heat |
| Process | GO:0042542 | response to hydrogen peroxide |
| Process | GO:0000302 | response to reactive oxygen species |
| Process | GO:0009651 | response to salt stress |
| Process | GO:0006986 | response to unfolded protein |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.00 | 1.00 |
| Trophozoite | expressed | 0.00 | 1.00 |
| Schizont | not expressed | 0.00 | 1.00 |
| Gametocyte | expressed | 0.03 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0816500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.429 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0714300)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0714300)
Modification: Disrupted | RMgm-2241
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IB02
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=13.91) with 5UMB (Global RMSD=23.19)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 7 | 7 | 7 |
| disruptive | 1 | 3 | 2 | 8 |
| missense | 1 | 3 | 2 | 7 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 19 | 5 | 9 |
| disruptive | 2 | 7 | 9 | 23 |
| missense | 2 | 6 | 9 | 13 |
PlasmoDB Total SNPs: 22
Non-coding: 19 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 172 | Molecular Weight (kDa): 19.371
UniProt ID(s): Q8IB02
PDB ID(s): None
Isoelectric Point: 4.93
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002068 | Alpha crystallin/Hsp20 domain |
| InterPro | IPR008978 | HSP20-like chaperone |
| InterPro | IPR031107 | Small heat shock protein HSP20 |
| PFam | PF00011 | Alpha crystallin/Hsp20 domain |
| Superfamily | SSF49764 | HSP20-like chaperone |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 26292257 | Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for VaccineDevelopment. | Aguiar JC, Bolton J, ..., Richie TL | 10.1371/journal.pone.0136109 |
| 28759593 | Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodiumvivax salivary gland sporozoites. | Swearingen KE, Lindner SE, ..., Mikolajczak SA | https://pubmed.ncbi.nlm.nih.gov/28759593/ |