PF3D7_0816700 (TRAPPC2L)

Genome location: Pf3D7_08_v3:766,329..767,961(+)

Genome classification: Core

Function and Localization

Product Description: trafficking protein particle complex subunit 2-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030008	TRAPP complex
Component	GO:0005737	cytoplasm
Component	GO:0005634	nucleus
Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	possibly expressed	0.14	0.90
Schizont	possibly expressed	0.05	0.97
Gametocyte	possibly expressed	0.18	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0816700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.13 | MFS: -2.646 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4V0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103373

Most Similar Human Ortholog: Q9UL33

TM-align score: 0.88 | RMSD: 1.74

Seq Identity: 0.26 | Length: 135 / 143

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000167515	trafficking protein particle complex 2 like

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	3	3	12
disruptive	0	3	5	20
missense	0	3	4	17

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	15	3	11
disruptive	1	23	16	27
missense	0	17	14	22

PlasmoDB Total SNPs: 90

Non-coding: 78 | Synonymous: 12 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 143 | Molecular Weight (kDa): 16.713

UniProt ID(s): C0H4V0

PDB ID(s): None

Isoelectric Point: 6.92

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006722	Trafficking protein particle complex subunit 2
InterPro	IPR011012	Longin-like domain superfamily
PFam	PF04628	Trafficking protein particle complex subunit 2
Superfamily	SSF64356	Longin-like domain superfamily