Product Description: meiotic recombination protein DMC1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000794 | condensed nuclear chromosome |
| Function | GO:0008094 | ATP-dependent activity, acting on DNA |
| Function | GO:0000150 | DNA strand exchange activity |
| Function | GO:0003690 | double-stranded DNA binding |
| Function | GO:0003697 | single-stranded DNA binding |
| Process | GO:0000730 | DNA recombinase assembly |
| Process | GO:0070192 | chromosome organization involved in meiotic cell cycle |
| Process | GO:0006312 | mitotic recombination |
| Process | GO:0007131 | reciprocal meiotic recombination |
| Process | GO:0010212 | response to ionizing radiation |
| Process | GO:0042148 | strand invasion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.00 | 1.00 |
| Trophozoite | expressed | 0.00 | 1.00 |
| Schizont | expressed | 0.00 | 1.00 |
| Gametocyte | expressed | 0.80 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0816800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.847 | MFS: -3.004 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0714000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0714000)
Modification: Disrupted | RMgm-2239
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IB05
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.10) with 3CMT (Global RMSD=8.57)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q06609 | DNA repair protein RAD51 homolog 1 | Homo sapiens | OrthoDB | MLS000727607cid_6602691Salazinic acid, 2Stictic acid (StA), 1... |
| P9WHJ3 | Protein RecA | Mycobacterium tuberculosis H37Rv | OrthoMCL BLAST | MLS000070448MLS000077061MLS000071738MLS000075325... |
Ortholog Group (OrthoMCL): OG6_100483
Most Similar Human Ortholog: Q06609
TM-align score: 0.93 | RMSD: 1.25
Seq Identity: 0.53 | Length: 323 / 347
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000051180 | RAD51 recombinase |
| ENSG00000100206 | DNA meiotic recombinase 1 |
Protein Length: 347 | Molecular Weight (kDa): 37.785
PDB ID(s): None
Isoelectric Point: 6.72
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR010995 | DNA repair Rad51/transcription factor NusA, alpha-helical |
| InterPro | IPR011940 | Meiotic recombination protein Dmc1 |
| InterPro | IPR013632 | DNA recombination and repair protein Rad51-like, C-terminal |
| InterPro | IPR016467 | DNA recombination and repair protein, RecA-like |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR033925 | Rad51/DMC1/RadA |
| PFam | PF08423 | DNA recombination and repair protein Rad51-like, C-terminal |
| Superfamily | SSF47794 | DNA repair Rad51/transcription factor NusA, alpha-helical |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 25 | 16 | 31 |
| disruptive | 3 | 13 | 6 | 14 |
| missense | 3 | 13 | 6 | 10 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 45 | 20 | 30 |
| disruptive | 7 | 21 | 13 | 42 |
| missense | 6 | 16 | 11 | 33 |
PlasmoDB Total SNPs: 128
Non-coding: 113 | Synonymous: 13 | Nonsynonymous: 2 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 37548404 | Recombinase-independent chromosomal rearrangements between dispersed invertedrepeats in Saccharomyces cerevisiae meiosis | Allison RM, Johnson DJ, Neale MJ, Gray S | 10.1093/nar/gkad650 |
| 38002960 | Homologous Recombination and Repair Functions Required for Mutagenicity duringYeast Meiosis | Morciano L, Elgrabli RM, Zenvirth D, Arbel-Eden A | 10.3390/genes14112017 |