PF3D7_0817200

Genome location: Pf3D7_08_v3:776,926..780,434(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.38	0.81
Trophozoite	expressed	0.37	0.77
Schizont	expressed	0.57	0.65
Gametocyte	expressed	0.37	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0817200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.141 | MFS: -3.131 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB08

"Best" AlphaFill ligand hit: BIO (biopterin, Local RMSD=0.61) with 1Y13 (Global RMSD=33.87)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_132913

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	43	18	44
disruptive	26	79	47	122
missense	17	72	45	109

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	69	35	57
disruptive	43	182	95	237
missense	29	152	78	169

PlasmoDB Total SNPs: 184

Non-coding: 101 | Synonymous: 62 | Nonsynonymous: 21 | Stop Codon: 0

Protein Information

Protein Length: 796 | Molecular Weight (kDa): 95.08

UniProt ID(s): Q8IB08

PDB ID(s): None

Isoelectric Point: 9.65

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A