PF3D7_0817300

Genome location: Pf3D7_08_v3:782,602..791,836(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.31	0.86
Trophozoite	expressed	1.30	0.39
Schizont	expressed	0.95	0.50
Gametocyte	expressed	0.73	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0817300

Resistome Missense Mutations: I389M

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 3 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.994 | MFS: -2.663 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0713500)

Modification: Disrupted | RMgm-2237

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB09

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_118163

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	21	123	54	121
disruptive	94	342	156	381
missense	50	252	119	267

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	49	229	91	134
disruptive	186	693	337	743
missense	107	511	244	414

PlasmoDB Total SNPs: 560

Non-coding: 203 | Synonymous: 243 | Nonsynonymous: 114 | Stop Codon: 0

Protein Information

Protein Length: 2235 | Molecular Weight (kDa): 254.752

UniProt ID(s): Q25774, Q8IB09

PDB ID(s): None

Isoelectric Point: 4.79

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF58104	N/A

PMID	Title	Authors	DOI/Link
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108