PF3D7_0817400

Genome location: Pf3D7_08_v3:794,136..798,695(-)

Genome classification: Core

Function and Localization

Product Description: phosphatase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion
Function	GO:0003690	double-stranded DNA binding
Function	GO:0046404	polydeoxyribonucleotide 5'-hydroxyl-kinase activity
Function	GO:0046403	polynucleotide 3'-phosphatase activity
Process	GO:0006281	DNA repair
Process	GO:0046939	nucleotide phosphorylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.08	0.96
Trophozoite	expressed	0.56	0.68
Schizont	expressed	0.11	0.92
Gametocyte	expressed	0.49	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0817400

Resistome Missense Mutations: L402I

Resistome Compounds with Missense Mutations: TCMDC-124553/MMV019869

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.21 | MFS: -3.386 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0713400)

Relative Growth Rate: 0.10 ± 0.06
Confidence: 7.03

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4V3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533363

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	26	18	37
disruptive	29	84	49	106
missense	19	63	41	82

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	52	20	49
disruptive	51	201	91	205
missense	28	137	72	105

PlasmoDB Total SNPs: 298

Non-coding: 175 | Synonymous: 54 | Nonsynonymous: 68 | Stop Codon: 1

Protein Information

Protein Length: 739 | Molecular Weight (kDa): 89.108

UniProt ID(s): C0H4V3

PDB ID(s): None

Isoelectric Point: 9.79

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013954	Polynucleotide kinase 3 phosphatase
InterPro	IPR036412	HAD-like superfamily
PFam	PF08645	Polynucleotide kinase 3 phosphatase
Superfamily	SSF56784	HAD-like superfamily