Product Description: histidine triad nucleotide-binding protein 1
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005783 | endoplasmic reticulum |
| Function | GO:0016787 | hydrolase activity |
| Function | GO:0008426 | protein kinase C inhibitor activity |
| Process | GO:0055074 | calcium ion homeostasis |
| Process | GO:0006508 | proteolysis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.66 | 0.70 |
| Trophozoite | expressed | 1.23 | 0.39 |
| Schizont | expressed | 0.46 | 0.73 |
| Gametocyte | expressed | 1.04 | 0.47 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0817500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.991 | MFS: -0.731 | #Insertions: 2
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0713300)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0713300)
Modification: Tagged | RMgm-4527
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q7K6B1
"Best" AlphaFill ligand hit: KAA (5'-o-[(l-lysylamino)sulfonyl]adenosine, Local RMSD=0.02) with 4EQE (Global RMSD=1.22)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P49773 | Adenosine 5'-monophosphoramidase HINT1 | Homo sapiens | OrthoDB, OrthoMCL BLAST | CHEMBL3140272 |
Ortholog Group (OrthoMCL): OG6_100377
Most Similar Human Ortholog: P49773
TM-align score: 0.94 | RMSD: 0.98
Seq Identity: 0.48 | Length: 125 / 185
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000137133 | histidine triad nucleotide binding protein 2 |
| ENSG00000169567 | histidine triad nucleotide binding protein 1 |
Protein Length: 185 | Molecular Weight (kDa): 21.177
PDB ID(s): None
Isoelectric Point: 9.68
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001310 | Histidine triad (HIT) protein |
| InterPro | IPR019808 | Histidine triad, conserved site |
| InterPro | IPR036265 | HIT-like superfamily |
| PFam | PF01230 | Histidine triad (HIT) protein |
| Superfamily | SSF54197 | HIT-like superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 203
Non-coding: 198 | Synonymous: 5 | Nonsynonymous: 0 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 29913151 | Plasmodium falciparum histidine triad protein and calmodulin modulates calciumhomeostasis and intracellular proteolysis. | Gomes Smaul MM, Budu A, ..., Gazarini ML | 10.1016/j.bbrc.2018.06.067 |
| 37371778 | Proteome Analysis of the Antiproliferative Activity of the NovelChitooligosaccharide-Gallic Acid Conjugate against the SW620 Colon Cancer CellLine | Saetang J, Sukkapat P, ..., Benjakul S | 10.3390/biomedicines11061683 |