PF3D7_0817600

Genome location: Pf3D7_08_v3:800,326..804,715(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	possibly expressed	0.12	0.94
Schizont	expressed	2.17	0.26
Gametocyte	expressed	0.67	0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0817600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.418 | MFS: -2.556 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0713200)

Relative Growth Rate: 0.05 ± 0.16
Confidence: 5.01

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB11

"Best" AlphaFill ligand hit: PCG (cyclic guanosine monophosphate, Local RMSD=6.70) with 5E16 (Global RMSD=44.00)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533203

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	47	26	66
disruptive	25	128	86	210
missense	21	124	81	194

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	103	42	79
disruptive	50	292	140	264
missense	38	263	131	207

PlasmoDB Total SNPs: 174

Non-coding: 97 | Synonymous: 34 | Nonsynonymous: 43 | Stop Codon: 0

Protein Information

Protein Length: 962 | Molecular Weight (kDa): 112.162

UniProt ID(s): Q8IB11

PDB ID(s): None

Isoelectric Point: 9.61

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108