Product Description: rhoptry neck protein 5
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0032991 | protein-containing complex |
| Component | GO:1990225 | rhoptry neck |
| Function | GO:0003723 | RNA binding |
| Function | GO:0046812 | host cell surface binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.08 | 0.96 |
| Trophozoite | expressed | 0.12 | 0.93 |
| Schizont | expressed | 2.22 | 0.23 |
| Gametocyte | expressed | 0.41 | 0.77 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0817700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.167 | MFS: -2.854 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0713100)
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0713100)
Modification: Mutated | RMgm-4867
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4V4
"Best" AlphaFill ligand hit: 144 (tris-hydroxymethyl-methyl-ammonium, Local RMSD=1.10) with 2RFM (Global RMSD=14.74)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 44 | 27 | 82 |
| disruptive | 21 | 32 | 23 | 80 |
| missense | 21 | 32 | 22 | 74 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 102 | 47 | 93 |
| disruptive | 30 | 88 | 78 | 197 |
| missense | 28 | 69 | 67 | 155 |
PlasmoDB Total SNPs: 757
Non-coding: 697 | Synonymous: 45 | Nonsynonymous: 15 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 21185360 | Identification of the Plasmodium falciparum rhoptry neck protein 5 (PfRON5). | Curtidor H, Patino LC, ..., Patarroyo MA | 10.1016/j.gene.2010.12.005 |
| 23932940 | Plasmodium falciparum rhoptry neck protein 5 peptides bind to human red bloodcells and inhibit parasite invasion. | Curtidor H, Patino LC, ..., Patarroyo MA | 10.1016/j.peptides.2013.07.028 |
| 32817376 | Detection of the Rhoptry Neck Protein Complex in Plasmodium Sporozoites and Its Contribution to Sporozoite Invasion of Salivary Glands | Nozaki M, Baba M, ..., Ishino T | 10.1128/mSphere.00325-20 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 31552198 | Expression and Localization Profiles of Rhoptry Proteins in Plasmodium bergheiSporozoites | Tokunaga N, Nozaki M, ..., Ishino T | 10.3389/fcimb.2019.00316 |
| 37272704 | Rhoptry neck protein 4 plays important roles during Plasmodium sporozoiteinfection of the mammalian liver | Baba M, Nozaki M, ..., Ishino T | 10.1128/msphere.00587-22 |
| 18952195 | Rhoptry neck protein RON2 forms a complex with microneme protein AMA1 inPlasmodium falciparum merozoites | Cao J, Kaneko O, ..., Torii M | 10.1016/j.parint.2008.09.005 |
| 30326220 | Deciphering ophthalmic adaptive inhibitors targeting RON4 of Toxoplasma gondii:An integrative in silico approach | Vetrivel U, Nagarajan H | 10.1016/j.lfs.2018.10.022 |
| 26821295 | Protective efficacy of pVAX-RON5p against acute and chronic infections ofToxoplasma gondii in BALB/c mice | Zhao Y, Li ZY, ..., Zhou DH | 10.1016/j.exppara.2016.01.011 |
| 20228060 | Interaction between Plasmodium falciparum apical membrane antigen 1 and therhoptry neck protein complex defines a key step in the erythrocyte invasionprocess of malaria parasites | Richard D, MacRaild CA, ..., Cowman AF | 10.1074/jbc.M109.080770 |
| 28848228 | Efficient invasion by Toxoplasma depends on the subversion of host proteinnetworks | Guerin A, Corrales RM, ..., Lebrun M | 10.1038/s41564-017-0018-1 |
| 24651769 | RON5 is critical for organization and function of the Toxoplasma moving junctioncomplex | Beck JR, Chen AL, Kim EW, Bradley PJ | 10.1371/journal.ppat.1004025 |
| 19247437 | Export of a Toxoplasma gondii rhoptry neck protein complex at the host cellmembrane to form the moving junction during invasion | Besteiro S, Michelin A, ..., Lebrun M | 10.1371/journal.ppat.1000309 |
| 30290224 | Plasmodium RON12 localizes to the rhoptry body in sporozoites | Oda-Yokouchi Y, Tachibana M, ..., Tsuboi T | 10.1016/j.parint.2018.10.001 |
| 19134112 | Novel components of the Apicomplexan moving junction reveal conserved andcoccidia-restricted elements | Straub KW, Cheng SJ, Sohn CS, Bradley PJ | 10.1111/j.1462-5822.2008.01276.x |
| 25888962 | The Plasmodium vivax rhoptry neck protein 5 is expressed in the apical pole ofPlasmodium vivax VCG-1 strain schizonts and binds to human reticulocytes | Arevalo-Pinzon G, Bermudez M, Curtidor H, Patarroyo MA | 10.1186/s12936-015-0619-1 |
| 29263399 | RON4(L1) is a new member of the moving junction complex in Toxoplasma gondii | Guerin A, El Hajj H, ..., Lebrun M | 10.1038/s41598-017-18010-9 |
| 25102354 | Expression and localization of rhoptry neck protein 5 in merozoites andsporozoites of Plasmodium yoelii | Mutungi JK, Yahata K, Sakaguchi M, Kaneko O | 10.1016/j.parint.2014.07.013 |