Product Description: high mobility group protein B2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005694 | chromosome |
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Function | GO:0003677 | DNA binding |
| Function | GO:0008301 | DNA binding, bending |
| Process | GO:0002720 | positive regulation of cytokine production involved in immune response |
| Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Process | GO:0006359 | regulation of transcription by RNA polymerase III |
| Process | GO:0006355 | regulation of transcription, DNA-templated |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.87 | 0.60 |
| Trophozoite | expressed | 1.64 | 0.29 |
| Schizont | expressed | 1.53 | 0.35 |
| Gametocyte | expressed | 1.94 | 0.29 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0817900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.368 | MFS: -3.27 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0712900)
Modification: Disrupted | RMgm-4831
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IB14
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_123380
Most Similar Human Ortholog: Q8WW32
TM-align score: 0.71 | RMSD: 2.08
Seq Identity: 0.32 | Length: 84 / 99
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000176256 | high mobility group box 4 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 57
Non-coding: 55 | Synonymous: 1 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 99 | Molecular Weight (kDa): 11.535
UniProt ID(s): Q8IB14
PDB ID(s): 2MRC
Isoelectric Point: 10.66
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR009071 | High mobility group box domain |
| InterPro | IPR036910 | High mobility group box domain superfamily |
| PFam | PF00505 | High mobility group box domain |
| Superfamily | SSF47095 | High mobility group box domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 16607015 | High-mobility-group box nuclear factors of Plasmodium falciparum. | Briquet S, Boschet C, ..., Vaquero C | 10.1128/EC.5.4.672-682.2006 |
| 18234548 | High mobility group box (HMGB) proteins of Plasmodium falciparum: DNA bindingproteins with pro-inflammatory activity. | Kumar K, Singal A, Rizvi MM, Chauhan VS | 10.1016/j.parint.2007.11.005 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |