PF3D7_0818000 (SNRNP27)

Genome location: Pf3D7_08_v3:819,137..822,699(+)

Genome classification: Core

Function and Localization

Product Description: U4/U6.U5 small nuclear ribonucleoprotein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.58	0.72
Trophozoite	expressed	0.58	0.67
Schizont	expressed	0.44	0.74
Gametocyte	expressed	0.61	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0818000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.922 | MFS: -2.193 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0712800)

Relative Growth Rate: 0.04 ± 0.06
Confidence: 6.97

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4V5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103584

Most Similar Human Ortholog: B8ZZ98

TM-align score: 0.24 | RMSD: 4.20

Seq Identity: 0.11 | Length: 55 / 372

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000124380	small nuclear ribonucleoprotein U4/U6.U5 subunit 27

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	29	14	24
disruptive	28	109	50	77
missense	19	71	40	61

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	46	21	19
disruptive	48	178	54	113
missense	27	130	42	76

PlasmoDB Total SNPs: 235

Non-coding: 187 | Synonymous: 23 | Nonsynonymous: 25 | Stop Codon: 0

Protein Information

Protein Length: 372 | Molecular Weight (kDa): 45.156

UniProt ID(s): C0H4V5

PDB ID(s): None

Isoelectric Point: 11.03

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013957	U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein
PFam	PF08648	U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein
Superfamily	N/A	N/A