PF3D7_0818100 (CZIF2)

Genome location: Pf3D7_08_v3:823,912..827,305(+)

Genome classification: Core

Function and Localization

Product Description: C3H1-type zinc finger protein CZIF2

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005829	cytosol
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.31	0.89
Trophozoite	possibly expressed	0.05	0.97
Schizont	expressed	0.36	0.89
Gametocyte	possibly expressed	0.05	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0818100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.986 | MFS: -2.694 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0712700)

Relative Growth Rate: 1.02 ± 0.06
Confidence: 7.13

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0712700)

Modification: Disrupted | RMgm-2231

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB16

"Best" AlphaFill ligand hit: ORO (orotic acid, Local RMSD=36.33) with 7S87 (Global RMSD=31.68)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533699

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	27	23	25
disruptive	12	50	36	74
missense	11	49	35	68

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	60	24	36
disruptive	16	120	59	150
missense	12	113	48	106

PlasmoDB Total SNPs: 212

Non-coding: 174 | Synonymous: 24 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 538 | Molecular Weight (kDa): 63.608

UniProt ID(s): Q8IB16

PDB ID(s): None

Isoelectric Point: 8.61

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A