PF3D7_0818300

Genome location: Pf3D7_08_v3:833,185..835,334(+)

Genome classification: Core

Function and Localization

Product Description: dynactin subunit 6, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005869	dynactin complex
Function	GO:0070840	dynein complex binding
Process	GO:0007052	mitotic spindle organization

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.13	0.93
Trophozoite	not expressed	0.05	0.97
Schizont	not expressed	0.11	0.93
Gametocyte	expressed	0.25	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0818300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.033 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0712500)

Relative Growth Rate: 1.00 ± 0.12
Confidence: 5.57

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0712500)

Modification: Disrupted | RMgm-2229

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB18

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104025

Most Similar Human Ortholog: E5RFU3

TM-align score: 0.65 | RMSD: 2.25

Seq Identity: 0.13 | Length: 60 / 560

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000104671	dynactin subunit 6

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	22	13	31
disruptive	18	75	32	108
missense	18	73	30	97

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	49	20	37
disruptive	38	150	65	158
missense	32	129	60	127

PlasmoDB Total SNPs: 89

Non-coding: 43 | Synonymous: 24 | Nonsynonymous: 22 | Stop Codon: 0

Protein Information

Protein Length: 560 | Molecular Weight (kDa): 66.313

UniProt ID(s): Q8IB18

PDB ID(s): None

Isoelectric Point: 10.12

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011004	Trimeric LpxA-like superfamily
InterPro	IPR027777	Dynactin subunit 6
PFam	N/A	N/A
Superfamily	SSF51161	Trimeric LpxA-like superfamily