Product Description: rRNA-processing protein FCF1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005730 | nucleolus |
| Component | GO:0032040 | small-subunit processome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.10 | 0.95 |
| Trophozoite | expressed | 0.12 | 0.93 |
| Schizont | expressed | 0.02 | 0.99 |
| Gametocyte | expressed | 0.09 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0818400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.123 | MFS: -2.918 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4V7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101337
Most Similar Human Ortholog: G3V2M5
TM-align score: 0.95 | RMSD: 0.64
Seq Identity: 0.61 | Length: 61 / 198
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000119616 | FCF1 rRNA-processing protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 10 | 10 | 17 |
| disruptive | 1 | 8 | 3 | 13 |
| missense | 1 | 6 | 3 | 13 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 27 | 8 | 14 |
| disruptive | 7 | 16 | 14 | 42 |
| missense | 3 | 13 | 13 | 36 |
PlasmoDB Total SNPs: 145
Non-coding: 130 | Synonymous: 13 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 198 | Molecular Weight (kDa): 23.159
UniProt ID(s): C0H4V7
PDB ID(s): None
Isoelectric Point: 10.17
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002716 | PIN domain |
| InterPro | IPR006984 | rRNA-processing protein Fcf1/Utp23 |
| InterPro | IPR029060 | PIN-like domain superfamily |
| PFam | PF04900 | rRNA-processing protein Fcf1/Utp23 |
| Superfamily | SSF88723 | PIN-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16762320 | Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved inpre-rRNA processing | Rempola B, Karkusiewicz I, Piekarska I, Rytka J | 10.1016/j.bbrc.2006.05.140 |
| 28082392 | The ribosome biogenesis factor yUtp23/hUTP23 coordinates key interactions in theyeast and human pre-40S particle and hUTP23 contains an essential PIN domain | Wells GR, Weichmann F, ..., Schneider C | 10.1093/nar/gkw1344 |