PF3D7_0818500

Genome location: Pf3D7_08_v3:841,264..844,248(+)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0008270	zinc ion binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.82	0.62
Trophozoite	expressed	0.40	0.76
Schizont	expressed	0.82	0.54
Gametocyte	expressed	0.82	0.56

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0818500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.999 | MFS: -2.618 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0712300)

Relative Growth Rate: 0.84 ± 0.13
Confidence: 5.49

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0712300)

Modification: Disrupted | RMgm-2228

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB20

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
Q6GQQ9	OTU domain-containing protein 7B		OrthoMCL BLAST	US10590075, Example 1US10590075, Example 2US10590075, Example 3US10590075, Example 4...

Orthology Information

Ortholog Group (OrthoMCL): OG6_101508

Most Similar Human Ortholog: H3BMJ5

TM-align score: 0.62 | RMSD: 1.35

Seq Identity: 0.48 | Length: 27 / 191

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000086666	zinc finger AN1-type containing 6
ENSG00000107372	zinc finger AN1-type containing 5

Protein Information

Protein Length: 191 | Molecular Weight (kDa): 22.179

UniProt ID(s): Q8IB20

PDB ID(s): None

Isoelectric Point: 6.81

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000058	Zinc finger, AN1-type
InterPro	IPR002653	Zinc finger, A20-type
InterPro	IPR035896	AN1-like Zinc finger
PFam	PF01428	Zinc finger, AN1-type
PFam	PF01754	Zinc finger, A20-type
Superfamily	SSF118310	AN1-like Zinc finger
Superfamily	SSF57716

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	1	0	0
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	1	0	0
disruptive	0	0	0	0
missense	0	0	0	0

PlasmoDB Total SNPs: 290

Non-coding: 281 | Synonymous: 9 | Nonsynonymous: 0 | Stop Codon: 0