Product Description: BEM46-like protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0016020 | membrane |
| Component | GO:0005886 | plasma membrane |
| Function | GO:0016298 | lipase activity |
| Function | GO:0008474 | palmitoyl-(protein) hydrolase activity |
| Process | GO:0048469 | cell maturation |
| Process | GO:0044409 | entry into host |
| Process | GO:0006629 | lipid metabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.09 | 0.95 |
| Trophozoite | expressed | 0.05 | 0.97 |
| Schizont | expressed | 0.07 | 0.95 |
| Gametocyte | expressed | 0.10 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0818600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.179 | MFS: -3.025 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0712200)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0712200)
Modification: Disrupted | RMgm-2227
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZYA4
"Best" AlphaFill ligand hit: D10 (decane, Local RMSD=0.04) with 8B9S (Global RMSD=2.92)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101827
Most Similar Human Ortholog: Q7L211
TM-align score: 0.86 | RMSD: 2.88
Seq Identity: 0.26 | Length: 290 / 302
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000139826 | abhydrolase domain containing 13 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 12 | 12 | 15 |
| disruptive | 25 | 14 | 9 | 21 |
| missense | 25 | 13 | 9 | 20 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 31 | 13 | 18 |
| disruptive | 26 | 41 | 26 | 74 |
| missense | 26 | 32 | 23 | 49 |
PlasmoDB Total SNPs: 185
Non-coding: 145 | Synonymous: 12 | Nonsynonymous: 27 | Stop Codon: 1
Protein Length: 302 | Molecular Weight (kDa): 34.921
UniProt ID(s): A0A143ZYA4
PDB ID(s): None
Isoelectric Point: 9.06
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR022742 | Serine aminopeptidase, S33 |
| InterPro | IPR029058 | Alpha/Beta hydrolase fold |
| PFam | PF12146 | Serine aminopeptidase, S33 |
| Superfamily | SSF53474 | Alpha/Beta hydrolase fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 26118838 | A Plasmodium alpha/beta-hydrolase modulates the development of invasive stages. | Groat-Carmona AM, Kain H, ..., Kappe SH | 10.1111/cmi.12477 |
| 27128092 | Interrogating the Plasmodium Sporozoite Surface: Identification ofSurface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP byMass Spectrometry-Based Proteomics. | Swearingen KE, Lindner SE, ..., Sinnis P | 10.1371/journal.ppat.1005606 |
| 31772212 | Functional annotation of serine hydrolases in the asexual erythrocytic stage ofPlasmodium falciparum. | Elahi R, Ray WK, ..., Klemba M | 10.1038/s41598-019-54009-0 |
| 14601879 | Effects of fish oil supplementation on the performance and the immunological,adrenal, and somatotropic responses of weaned pigs after an Escherichia colilipopolysaccharide challenge | Liu YL, Li DF, ..., Carroll JA | 10.2527/2003.81112758x |