PF3D7_0818800 (IMP4)

Genome location: Pf3D7_08_v3:855,347..857,162(-)

Genome classification: Core

Function and Localization

Product Description: U3 small nucleolar ribonucleoprotein protein IMP4, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0034457	Mpp10 complex
Component	GO:0005730	nucleolus
Component	GO:0032040	small-subunit processome
Component	GO:0005732	sno(s)RNA-containing ribonucleoprotein complex
Function	GO:0030515	snoRNA binding
Process	GO:0006396	RNA processing
Process	GO:0006364	rRNA processing
Process	GO:0042274	ribosomal small subunit biogenesis

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.57	0.72
Trophozoite	possibly expressed	0.32	0.82
Schizont	possibly expressed	0.11	0.94
Gametocyte	expressed	0.32	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0818800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.516 | MFS: -2.992 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0712000)

Relative Growth Rate: 0.03 ± 0.06
Confidence: 6.87

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB23

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102223

Most Similar Human Ortholog: B9A008

TM-align score: 0.97 | RMSD: 0.98

Seq Identity: 0.43 | Length: 172 / 362

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000136718	IMP U3 small nucleolar ribonucleoprotein 4

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	11	14	24
disruptive	1	23	25	36
missense	1	20	17	30

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	36	14	24
disruptive	2	62	41	83
missense	2	42	32	51

PlasmoDB Total SNPs: 111

Non-coding: 85 | Synonymous: 19 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 362 | Molecular Weight (kDa): 43.659

UniProt ID(s): Q8IB23

PDB ID(s): None

Isoelectric Point: 9.64

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007109	Brix domain
PFam	PF04427	Brix domain
Superfamily	SSF52954	N/A