PF3D7_0819100

Genome location: Pf3D7_08_v3:869,033..871,357(+)

Genome classification: Core

Function and Localization

Product Description: BRIX domain, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030687	preribosome, large subunit precursor
Function	GO:0019843	rRNA binding
Process	GO:0000027	ribosomal large subunit assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.53	0.74
Trophozoite	not expressed	0.34	0.80
Schizont	not expressed	0.06	0.96
Gametocyte	not expressed	0.24	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0819100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.467 | MFS: -3.421 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB26

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=3.35) with 5UJ7 (Global RMSD=14.13)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101976

Most Similar Human Ortholog: C9JHF7

TM-align score: 0.79 | RMSD: 2.27

Seq Identity: 0.15 | Length: 96 / 295

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000130810	peter pan homolog
ENSG00000243207	PPAN-P2RY11 readthrough

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	15	12	23
disruptive	4	23	14	46
missense	4	21	14	39

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	28	18	26
disruptive	16	64	30	82
missense	10	55	24	52

PlasmoDB Total SNPs: 98

Non-coding: 84 | Synonymous: 6 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 295 | Molecular Weight (kDa): 34.669

UniProt ID(s): Q8IB26

PDB ID(s): None

Isoelectric Point: 10.28

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007109	Brix domain
PFam	PF04427	Brix domain
Superfamily	N/A	N/A