PF3D7_0819300

Genome location: Pf3D7_08_v3:873,926..877,521(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	expressed	0.15	0.90
Schizont	possibly expressed	0.02	0.99
Gametocyte	not expressed	0.17	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0819300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.13 | MFS: -3.13 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4V9

"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=11.42) with 7LT5 (Global RMSD=14.62)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533052

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	51	21	66
disruptive	35	143	113	215
missense	29	129	105	185

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	100	41	71
disruptive	71	338	167	322
missense	49	288	142	228

PlasmoDB Total SNPs: 78

Non-coding: 6 | Synonymous: 46 | Nonsynonymous: 26 | Stop Codon: 0

Protein Information

Protein Length: 1043 | Molecular Weight (kDa): 125.469

UniProt ID(s): C0H4V9

PDB ID(s): None

Isoelectric Point: 9.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A