PF3D7_0819500

Genome location: Pf3D7_08_v3:881,047..884,462(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.04	0.98
Trophozoite	expressed	0.12	0.94
Schizont	not expressed	0.03	0.98
Gametocyte	expressed	0.42	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0819500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.803 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0711300)

Relative Growth Rate: 1.04 ± 0.14
Confidence: 5.38

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0711300)

Modification: Disrupted | RMgm-2222

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4W0

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=6.97) with 3VGJ (Global RMSD=16.42)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101806

Most Similar Human Ortholog: A0A087WXU0

TM-align score: 0.87 | RMSD: 2.00

Seq Identity: 0.27 | Length: 263 / 386

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000155906	required for meiotic nuclear division 1 homolog

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	19	13	32
disruptive	5	4	11	28
missense	5	4	9	27

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	48	20	21
disruptive	8	34	32	71
missense	5	22	25	50

PlasmoDB Total SNPs: 215

Non-coding: 197 | Synonymous: 10 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 386 | Molecular Weight (kDa): 45.683

UniProt ID(s): C0H4W0

PDB ID(s): None

Isoelectric Point: 5.54

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003734	Domain of unknown function DUF155
PFam	PF02582	Domain of unknown function DUF155
Superfamily	N/A	N/A