About Gene List

PF3D7_0819600

Genome location: Pf3D7_08_v3:884,484..887,623(-)

Genome classification: Core

Function and Localization

Product Description: ubiquitin-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.09 0.95
Trophozoite expressed 0.40 0.75
Schizont expressed 0.93 0.51
Gametocyte expressed 0.67 0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0819600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.082 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0711200)

  • Relative Growth Rate: 1.01 ± 0.10
  • Confidence: 6.04

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0711200)

Modification: Disrupted | RMgm-2221

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB31

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146115

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 0 0 0
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 0 0 1
missense 0 0 0 0

PlasmoDB Total SNPs: 206

Non-coding: 178 | Synonymous: 19 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 277 | Molecular Weight (kDa): 32.165

UniProt ID(s): Q8IB31

PDB ID(s): None

Isoelectric Point: 4.93

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000626 Ubiquitin-like domain
InterPro IPR029071 Ubiquitin-like domain superfamily
PFam PF00240 Ubiquitin-like domain
Superfamily SSF54236 Ubiquitin-like domain superfamily

Associated Publications

PMID Title Authors DOI/Link
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108