About Gene List

PF3D7_0819700

Genome location: Pf3D7_08_v3:888,126..890,471(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.06 0.97
Trophozoite expressed 0.41 0.75
Schizont expressed 0.49 0.69
Gametocyte expressed 0.33 0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0819700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.134 | MFS: -2.769 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4W1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_140451

Most Similar Human Ortholog: Q5MJ10

TM-align score: 0.29 | RMSD: 6.04

Seq Identity: 0.10 | Length: 100 / 781

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000268988 SPANX family member N2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 19 14 33
disruptive 19 59 57 80
missense 18 54 56 68

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 41 23 43
disruptive 38 160 60 143
missense 34 136 48 85

PlasmoDB Total SNPs: 169

Non-coding: 0 | Synonymous: 101 | Nonsynonymous: 68 | Stop Codon: 0

Protein Information

Protein Length: 781 | Molecular Weight (kDa): 95.04

UniProt ID(s): C0H4W1

PDB ID(s): None

Isoelectric Point: 9.26

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596