PF3D7_0819800

Genome location: Pf3D7_08_v3:891,658..898,502(-)

Genome classification: Core

Function and Localization

Product Description: tetratricopeptide repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.11	0.95
Trophozoite	not expressed	0.44	0.77
Schizont	not expressed	0.66	0.67
Gametocyte	not expressed	1.34	0.44

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0819800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.399 | #Insertions: 10

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0711000)

Modification: Disrupted | RMgm-2220

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB33

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533391

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	19	71	35	103
disruptive	63	210	113	286
missense	42	181	95	250

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	33	136	58	105
disruptive	108	420	187	379
missense	68	347	157	282

PlasmoDB Total SNPs: 463

Non-coding: 289 | Synonymous: 106 | Nonsynonymous: 68 | Stop Codon: 0

Protein Information

Protein Length: 1408 | Molecular Weight (kDa): 170.278

UniProt ID(s): Q8IB33

PDB ID(s): None

Isoelectric Point: 6.78

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
InterPro	IPR040163	RP1/RP1L1/DCX
PFam	N/A	N/A
Superfamily	SSF48452	Tetratricopeptide-like helical domain superfamily