Product Description: U6 snRNA-associated Sm-like protein LSm3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:1990726 | Lsm1-7-Pat1 complex |
| Component | GO:0000932 | P-body |
| Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Component | GO:0005688 | U6 snRNP |
| Component | GO:0071013 | catalytic step 2 spliceosome |
| Component | GO:0005634 | nucleus |
| Component | GO:0071011 | precatalytic spliceosome |
| Component | GO:0005732 | sno(s)RNA-containing ribonucleoprotein complex |
| Function | GO:0003723 | RNA binding |
| Process | GO:0033962 | P-body assembly |
| Process | GO:0008380 | RNA splicing |
| Process | GO:0000375 | RNA splicing, via transesterification reactions |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.18 | 0.91 |
| Trophozoite | no data | 0.30 | 0.81 |
| Schizont | no data | 0.07 | 0.95 |
| Gametocyte | no data | 0.35 | 0.79 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0819900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.137 | MFS: -3.136 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4W2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101597
Most Similar Human Ortholog: P62310
TM-align score: 0.85 | RMSD: 1.52
Seq Identity: 0.45 | Length: 87 / 91
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000170860 | LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 4 | 3 | 2 |
| disruptive | 2 | 5 | 3 | 8 |
| missense | 2 | 5 | 3 | 8 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 8 | 3 | 4 |
| disruptive | 3 | 12 | 8 | 17 |
| missense | 3 | 12 | 7 | 12 |
PlasmoDB Total SNPs: 50
Non-coding: 44 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 91 | Molecular Weight (kDa): 10.701
UniProt ID(s): C0H4W2
PDB ID(s): None
Isoelectric Point: 4.91
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001163 | LSM domain, eukaryotic/archaea-type |
| InterPro | IPR010920 | LSM domain superfamily |
| InterPro | IPR034105 | Sm-like protein Lsm3 |
| InterPro | IPR040002 | U6 snRNA-associated Sm-like protein Lsm3 |
| PFam | PF01423 | LSM domain, eukaryotic/archaea-type |
| Superfamily | SSF50182 | LSM domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 29615482 | Defining essential elements and genetic interactions of the yeast Lsm2-8 ring anddemonstration that essentiality of Lsm2-8 is bypassed via overexpression of U6snRNA or the U6 snRNP subunit Prp24 | Roth AJ, Shuman S, Schwer B | 10.1261/rna.066175.118 |