Product Description: Snf2-related CBP activator, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000812 | Swr1 complex |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0016020 | membrane |
| Component | GO:0005634 | nucleus |
| Function | GO:0005524 | ATP binding |
| Function | GO:0016887 | ATP hydrolysis activity |
| Function | GO:0004386 | helicase activity |
| Function | GO:0042393 | histone binding |
| Function | GO:0003713 | transcription coactivator activity |
| Process | GO:0043044 | ATP-dependent chromatin remodeling |
| Process | GO:0006338 | chromatin remodeling |
| Process | GO:0016458 | gene silencing |
| Process | GO:0043486 | histone exchange |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.76 | 0.65 |
| Trophozoite | expressed | 1.05 | 0.47 |
| Schizont | expressed | 0.27 | 0.83 |
| Gametocyte | expressed | 0.95 | 0.52 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0820000
Resistome Missense Mutations: K1871N
Resistome Compounds with Missense Mutations: DSM1
Resistome # Samples with Disruptive Mutations: 6 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.992 | MFS: -2.797 | #Insertions: 1
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0710800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4W3
"Best" AlphaFill ligand hit: CXS (3-cyclohexyl-1-propylsulfonic acid, Local RMSD=0.21) with 2WAX (Global RMSD=4.23)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101779
Most Similar Human Ortholog: C9J4U4
TM-align score: 0.33 | RMSD: 4.28
Seq Identity: 0.07 | Length: 57 / 2082
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000080603 | Snf2 related CREBBP activator protein |
| ENSG00000183495 | E1A binding protein p400 |
| ENSG00000282034 | novel transcript |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 28 | 105 | 53 | 140 |
| disruptive | 128 | 244 | 127 | 285 |
| missense | 53 | 178 | 104 | 218 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 43 | 216 | 73 | 143 |
| disruptive | 181 | 498 | 211 | 483 |
| missense | 84 | 361 | 148 | 315 |
PlasmoDB Total SNPs: 413
Non-coding: 170 | Synonymous: 132 | Nonsynonymous: 111 | Stop Codon: 0
Protein Length: 2082 | Molecular Weight (kDa): 246.748
UniProt ID(s): C0H4W3
PDB ID(s): None
Isoelectric Point: 5.12
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000330 | SNF2-related, N-terminal domain |
| InterPro | IPR001650 | Helicase, C-terminal |
| InterPro | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| InterPro | IPR014012 | Helicase/SANT-associated domain |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF00176 | SNF2-related, N-terminal domain |
| PFam | PF00271 | Helicase, C-terminal |
| PFam | PF07529 | Helicase/SANT-associated domain |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 12743798 | Molecular cloning and characterization of an SRCAP chromatin remodeling homologuein Toxoplasma gondii. | Sullivan WJ Jr, Monroy MA, ..., Queener SF | 10.1007/s00436-002-0814-1 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 17653272 | Rapid identification of malaria vaccine candidates based on alpha-helical coiledcoil protein motif. | Villard V, Agak GW, ..., Corradin G | 10.1371/journal.pone.0000645 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |