PF3D7_0820100

Genome location: Pf3D7_08_v3:909,083..910,928(-)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: MIFLYFPFVLLLCTFLINFAKC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	not expressed	0.42	0.75
Schizont	not expressed	0.05	0.97
Gametocyte	not expressed	0.58	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0820100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.053 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0710700)

Relative Growth Rate: 0.03 ± 0.04
Confidence: 7.84

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4W4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215339

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	15	11	22
disruptive	2	30	18	61
missense	2	29	17	56

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	34	18	24
disruptive	6	84	47	102
missense	3	67	41	60

PlasmoDB Total SNPs: 76

Non-coding: 54 | Synonymous: 13 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 359 | Molecular Weight (kDa): 43.129

UniProt ID(s): C0H4W4

PDB ID(s): None

Isoelectric Point: 10.33

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A