PF3D7_0820300

Genome location: Pf3D7_08_v3:917,497..921,911(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.02	0.54
Trophozoite	expressed	0.45	0.74
Schizont	expressed	0.62	0.62
Gametocyte	expressed	0.46	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0820300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.334 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0710500)

Modification: Disrupted | RMgm-2217

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB38

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533639

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	39	20	37
disruptive	46	130	83	143
missense	39	114	72	121

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	73	30	41
disruptive	90	263	104	199
missense	60	226	83	126

PlasmoDB Total SNPs: 346

Non-coding: 222 | Synonymous: 72 | Nonsynonymous: 52 | Stop Codon: 0

Protein Information

Protein Length: 613 | Molecular Weight (kDa): 72.276

UniProt ID(s): Q8IB38

PDB ID(s): None

Isoelectric Point: 8.7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A