About Gene List

PF3D7_0820400

Genome location: Pf3D7_08_v3:921,931..924,596(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0044228 host cell surface
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.03 0.98
Trophozoite not expressed 0.14 0.91
Schizont not expressed 0.03 0.98
Gametocyte expressed 0.20 0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0820400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -3.167 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB39

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533285

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 25 6 40
disruptive 12 72 38 74
missense 10 70 38 67

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 50 15 43
disruptive 18 153 66 173
missense 15 138 48 116

PlasmoDB Total SNPs: 119

Non-coding: 101 | Synonymous: 8 | Nonsynonymous: 9 | Stop Codon: 1

Protein Information

Protein Length: 499 | Molecular Weight (kDa): 60.74

UniProt ID(s): Q8IB39

PDB ID(s): None

Isoelectric Point: 8.35

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
29162636 Quantitative Proteomic Profiling Reveals Novel Plasmodium falciparum SurfaceAntigens and Possible Vaccine Candidates. Nilsson Bark SK, Ahmad R, ..., Marti M 10.1074/mcp.RA117.000076
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21