About Gene List

PF3D7_0820500 (YIF1)

Genome location: Pf3D7_08_v3:925,054..927,974(+)

Genome classification: Core

Function and Localization

Product Description: protein transport protein YIF1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 7

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0030134 COPII-coated ER to Golgi transport vesicle
Component GO:0005789 endoplasmic reticulum membrane
Component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
Component GO:0030173 integral component of Golgi membrane
Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.59 0.71
Trophozoite expressed 0.39 0.76
Schizont expressed 0.28 0.80
Gametocyte possibly expressed 0.57 0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0820500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.141 | MFS: -2.885 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB40

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532899

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 64 33 60
disruptive 37 141 78 183
missense 24 116 70 139

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 20 111 38 62
disruptive 78 323 142 329
missense 51 240 112 170

PlasmoDB Total SNPs: 122

Non-coding: 37 | Synonymous: 58 | Nonsynonymous: 27 | Stop Codon: 0

Protein Information

Protein Length: 852 | Molecular Weight (kDa): 98.561

UniProt ID(s): O96563, O96598, Q8IB40

PDB ID(s): None

Isoelectric Point: 9.58

Protein Domain Annotations:

Source Family ID Description
InterPro IPR005578 Yif1 family
PFam PF03878 Yif1 family
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
21441304 Btn3 is a negative regulator of Btn2-mediated endosomal protein trafficking andprion curing in yeast Kanneganti V, Kama R, Gerst JE 10.1091/mbc.E10-11-0878
12615067 The yeast model for Batten disease: a role for Btn2p in the trafficking of theGolgi-associated vesicular targeting protein, Yif1p Chattopadhyay S, Roberts PM, Pearce DA 10.1016/s0006-291x(03)00209-2
17101785 Btn2, a Hook1 ortholog and potential Batten disease-related protein, mediateslate endosome-Golgi protein sorting in yeast Kama R, Robinson M, Gerst JE 10.1128/MCB.00699-06