PF3D7_0820600

Genome location: Pf3D7_08_v3:928,546..930,946(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MNLFSFLIFLLLLFFINLFFVKS

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	possibly expressed	0.04	0.97
Schizont	expressed	0.08	0.94
Gametocyte	expressed	0.11	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0820600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.773 | MFS: -1.942 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0710200)

Relative Growth Rate: 1.02 ± 0.08
Confidence: 6.33

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0710200)

Modification: Disrupted | RMgm-2216

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB41

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_112393

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	20	16	33
disruptive	5	21	25	56
missense	5	21	23	48

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	53	24	36
disruptive	8	84	56	129
missense	6	66	47	86

PlasmoDB Total SNPs: 130

Non-coding: 101 | Synonymous: 24 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 455 | Molecular Weight (kDa): 54.574

UniProt ID(s): Q8IB41

PDB ID(s): None

Isoelectric Point: 10.4

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A