PF3D7_0820900

Genome location: Pf3D7_08_v3:939,305..944,689(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.45	0.79
Trophozoite	not expressed	0.72	0.62
Schizont	possibly expressed	0.84	0.58
Gametocyte	not expressed	0.98	0.52

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0820900

Resistome Missense Mutations: Q1353K

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 2 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -2.974 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0709900)

Relative Growth Rate: 0.88 ± 0.18
Confidence: 4.85

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0709900)

Modification: Disrupted | RMgm-2214

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB43

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533243

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	18	84	52	104
disruptive	81	325	148	412
missense	67	307	139	359

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	31	176	77	109
disruptive	171	643	261	560
missense	133	548	222	386

PlasmoDB Total SNPs: 289

Non-coding: 107 | Synonymous: 68 | Nonsynonymous: 114 | Stop Codon: 0

Protein Information

Protein Length: 1576 | Molecular Weight (kDa): 191.386

UniProt ID(s): Q8IB43

PDB ID(s): None

Isoelectric Point: 9.4

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A