PF3D7_0821000

Genome location: Pf3D7_08_v3:948,437..951,284(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0003723	RNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.04	0.98
Trophozoite	no data	0.39	0.76
Schizont	no data	0.51	0.68
Gametocyte	no data	0.16	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0821000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.203 | MFS: -2.654 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB44

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.87) with 8BNS (Global RMSD=15.55)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109963

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	33	8	32
disruptive	1	11	11	42
missense	1	11	9	37

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	66	19	32
disruptive	3	57	53	109
missense	2	38	36	59

PlasmoDB Total SNPs: 203

Non-coding: 170 | Synonymous: 30 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 514 | Molecular Weight (kDa): 60.543

UniProt ID(s): Q8IB44

PDB ID(s): None

Isoelectric Point: 9.38

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR022812	Dynamin superfamily
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
PFam	PF00350	Dynamin superfamily
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase