Product Description: protein kinase 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.7.11.1 (Non-specific serine/threonine protein kinase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005829 | cytosol |
| Function | GO:0004674 | protein serine/threonine kinase activity |
| Process | GO:0007165 | signal transduction |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 1.29 | 0.46 |
| Trophozoite | not expressed | 0.60 | 0.66 |
| Schizont | not expressed | 0.41 | 0.75 |
| Gametocyte | not expressed | 0.28 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0821100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.634 | #Insertions: 5
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0709700)
Modification: Disrupted | RMgm-527
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4W5
"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=0.19) with 1B39 (Global RMSD=7.59)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.11.1 | non-specific serine/threonine protein kinase | ATPKClDTTP53DRBEDTATBCAKN-93K252aCKI-7LAALSTAACS... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 31 | 22 | 43 |
| disruptive | 35 | 116 | 59 | 160 |
| missense | 22 | 84 | 53 | 130 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 68 | 34 | 52 |
| disruptive | 54 | 243 | 130 | 275 |
| missense | 33 | 182 | 102 | 177 |
PlasmoDB Total SNPs: 247
Non-coding: 131 | Synonymous: 72 | Nonsynonymous: 44 | Stop Codon: 0
Protein Length: 918 | Molecular Weight (kDa): 107.246
PDB ID(s): None
Isoelectric Point: 6.72
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000719 | Protein kinase domain |
| InterPro | IPR008271 | Serine/threonine-protein kinase, active site |
| InterPro | IPR011009 | Protein kinase-like domain superfamily |
| InterPro | IPR017441 | Protein kinase, ATP binding site |
| PFam | PF00069 | Protein kinase domain |
| Superfamily | SSF56112 | Protein kinase-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 8538687 | A Plasmodium falciparum protein kinase with two unusually large kinase inserts. | Kappes B, Yang J, ..., Franklin RM | 10.1016/0166-6851(95)00075-c |
| 38196495 | Genetic diversity of Toxoplasma gondii in goats and sheep from the NortheastRegion of Brazil destined for human consumption | Feitosa TF, Vilela VLR, ..., Bartley PM | 10.1016/j.crpvbd.2023.100163 |
| 38040112 | Detection of Toxoplasma gondii and Sarcocystis sp. in the meat of common minkewhale (Balaenoptera acutorostrata): A case of suspected food poisoning in Japan | Murata R, Kodo Y, ..., Nagamune K | 10.1016/j.parint.2023.102832 |
| 38055433 | Molecular characterization and epidemiology of Toxoplasma gondii isolates fromfree-range chickens in the southwest region of Goias: new genotypes | Domann N, Rezende SR, ..., Rezende HHA | 10.1590/S1984-29612023069 |
| 38379406 | Genotyping of Toxoplasma gondii in domestic animals from Campeche, Mexico,reveals virulent genotypes and a recombinant ROP5 allele | Rico-Torres CP, Valenzuela-Moreno LF, ..., Caballero-Ortega H | 10.1017/S0031182024000106 |