PF3D7_0821200

Genome location: Pf3D7_08_v3:957,099..958,258(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.13	0.93
Trophozoite	not expressed	0.13	0.91
Schizont	expressed	0.05	0.97
Gametocyte	not expressed	0.17	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0821200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.177 | MFS: -2.84 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB46

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_118066

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	7	7	11
disruptive	4	13	11	37
missense	4	11	10	33

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	15	5	18
disruptive	6	41	22	47
missense	5	37	18	31

PlasmoDB Total SNPs: 48

Non-coding: 36 | Synonymous: 6 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 191 | Molecular Weight (kDa): 22.272

UniProt ID(s): Q8IB46

PDB ID(s): None

Isoelectric Point: 10.13

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A