PF3D7_0821400

Genome location: Pf3D7_08_v3:964,289..967,130(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.42	0.79
Trophozoite	possibly expressed	0.26	0.83
Schizont	expressed	0.30	0.80
Gametocyte	expressed	0.09	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0821400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.282 | MFS: -2.757 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0709400)

Relative Growth Rate: 0.23 ± 0.08
Confidence: 6.41

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0709400)

Modification: Disrupted | RMgm-2212

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB48

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532777

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 174

Non-coding: 164 | Synonymous: 3 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 124 | Molecular Weight (kDa): 14.06

UniProt ID(s): Q8IB48

PDB ID(s): None

Isoelectric Point: 10.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A