About Gene List

PF3D7_0821700

Genome location: Pf3D7_08_v3:972,554..974,543(+)

Genome classification: Core

Function and Localization

Product Description: 60S ribosomal protein L22, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0022625 cytosolic large ribosomal subunit
Component GO:0005634 nucleus
Function GO:0003723 RNA binding
Function GO:0003735 structural constituent of ribosome
Process GO:0002181 cytoplasmic translation
Process GO:0006412 translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 1.12 0.53
Trophozoite expressed 1.54 0.33
Schizont expressed 0.23 0.85
Gametocyte expressed 0.65 0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0821700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.123 | MFS: -3.35 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0709100)

  • Relative Growth Rate: 0.12 ± 0.28
  • Confidence: 3.95

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB51

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101015

Most Similar Human Ortholog: K7ELC4

TM-align score: 0.96 | RMSD: 0.58

Seq Identity: 0.46 | Length: 78 / 139

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000116251 ribosomal protein L22
ENSG00000163584 ribosomal protein L22 like 1
ENSG00000285629 novel transcript

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 6 3 7
disruptive 0 3 3 3
missense 0 3 3 3

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 15 4 15
disruptive 0 14 10 25
missense 0 10 8 18

PlasmoDB Total SNPs: 159

Non-coding: 152 | Synonymous: 7 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 139 | Molecular Weight (kDa): 16.382

UniProt ID(s): Q8IB51

PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD

Isoelectric Point: 10.85

Protein Domain Annotations:

Source Family ID Description
InterPro IPR002671 Ribosomal protein L22e
PFam PF01776 Ribosomal protein L22e
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
24913268 Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine Wong W, Bai XC, ..., Scheres SH 10.7554/eLife.03080
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596