Product Description: protein transport protein SEC61 subunit beta, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005784 | Sec61 translocon complex |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0031205 | endoplasmic reticulum Sec complex |
| Component | GO:0005634 | nucleus |
| Process | GO:0006616 | SRP-dependent cotranslational protein targeting to membrane, translocation |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0031204 | posttranslational protein targeting to membrane, translocation |
| Process | GO:0043952 | protein transport by the Sec complex |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.19 | 0.91 |
| Trophozoite | expressed | 0.38 | 0.76 |
| Schizont | expressed | 0.21 | 0.85 |
| Gametocyte | expressed | 0.33 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0821800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.732 | MFS: -2.128 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0709000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4W6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103007
Most Similar Human Ortholog: S4R3B5
TM-align score: 0.61 | RMSD: 2.25
Seq Identity: 0.49 | Length: 35 / 80
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000106803 | SEC61 translocon subunit beta |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 1 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 140
Non-coding: 138 | Synonymous: 1 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 80 | Molecular Weight (kDa): 8.63
UniProt ID(s): C0H4W6
PDB ID(s): None
Isoelectric Point: 12.25
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR016482 | Protein transport protein SecG/Sec61-beta/Sbh |
| InterPro | IPR030671 | Protein transport Sec61-beta/Sbh |
| PFam | PF03911 | Protein transport protein SecG/Sec61-beta/Sbh |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 17919451 | Unraveling the components of protein translocation pathway in human malariaparasite Plasmodium falciparum. | Tuteja R | 10.1016/j.abb.2007.08.031 |
| 27566438 | High resolution microscopy reveals an unusual architecture of the Plasmodiumberghei endoplasmic reticulum. | Kaiser G, De Niz M, ..., Stanway RR | 10.1111/mmi.13490 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 37805802 | [Influence of family with sequence similarity 134, member B-mediatedreticulophagy on lipopolysaccharide-induced apoptosis of mouse dendritic cells] | Duan Y, Yao RQ, ..., Dai XG | 10.3760/cma.j.cn501225-20230227-00063 |