PF3D7_0821900

Genome location: Pf3D7_08_v3:976,989..978,474(-)

Genome classification: Core

Function and Localization

Product Description: WPP motif-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.01	0.99
Trophozoite	expressed	0.12	0.92
Schizont	expressed	0.02	0.99
Gametocyte	expressed	0.05	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0821900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.169 | MFS: -2.586 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0708900)

Modification: Tagged | RMgm-4965

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4W7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_149551

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	6	3	8
disruptive	0	4	2	17
missense	0	4	2	15

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	12	4	6
disruptive	1	15	11	38
missense	1	10	6	26

PlasmoDB Total SNPs: 129

Non-coding: 118 | Synonymous: 11 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 107 | Molecular Weight (kDa): 13.077

UniProt ID(s): C0H4W7

PDB ID(s): None

Isoelectric Point: 9.38

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A