Product Description: ribosomal protein L4, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003735 | structural constituent of ribosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.07 | 0.97 |
| Trophozoite | expressed | 0.45 | 0.73 |
| Schizont | expressed | 0.11 | 0.93 |
| Gametocyte | expressed | 0.22 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0822000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.296 | MFS: -2.667 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IB54
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101056
Most Similar Human Ortholog: K7EJ73
TM-align score: 0.84 | RMSD: 1.83
Seq Identity: 0.22 | Length: 118 / 568
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000105364 | mitochondrial ribosomal protein L4 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 31 | 15 | 31 |
| disruptive | 2 | 51 | 30 | 87 |
| missense | 2 | 40 | 27 | 70 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 61 | 17 | 32 |
| disruptive | 24 | 92 | 71 | 157 |
| missense | 10 | 75 | 59 | 97 |
PlasmoDB Total SNPs: 116
Non-coding: 69 | Synonymous: 36 | Nonsynonymous: 11 | Stop Codon: 0
Protein Length: 568 | Molecular Weight (kDa): 67.894
UniProt ID(s): Q8IB54
PDB ID(s): None
Isoelectric Point: 7.29
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002136 | Ribosomal protein L4/L1e |
| InterPro | IPR013005 | 50S ribosomal protein uL4 |
| InterPro | IPR023574 | Ribosomal protein L4 domain superfamily |
| PFam | PF00573 | Ribosomal protein L4/L1e |
| Superfamily | SSF52166 | Ribosomal protein L4 domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 17604309 | Reconstructing the evolution of the mitochondrial ribosomal proteome. | Smits P, Smeitink JA, ..., Ettema TJ | 10.1093/nar/gkm441 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |