Product Description: mediator of RNA polymerase II transcription subunit 7, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0070847 | core mediator complex |
| Component | GO:0016592 | mediator complex |
| Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.20 | 0.90 |
| Trophozoite | possibly expressed | 0.25 | 0.85 |
| Schizont | not expressed | 0.02 | 0.99 |
| Gametocyte | not expressed | 0.81 | 0.56 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0822100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.171 | MFS: -3.325 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IB55
"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=7.15) with 3HAV (Global RMSD=24.04)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 10 | 11 | 12 |
| disruptive | 3 | 20 | 15 | 40 |
| missense | 3 | 18 | 12 | 31 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 24 | 10 | 11 |
| disruptive | 9 | 56 | 36 | 55 |
| missense | 5 | 44 | 23 | 41 |
PlasmoDB Total SNPs: 93
Non-coding: 79 | Synonymous: 9 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 234 | Molecular Weight (kDa): 28.197
UniProt ID(s): Q8IB55
PDB ID(s): None
Isoelectric Point: 9.26
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR009244 | Mediator complex, subunit Med7 |
| InterPro | IPR037212 | Mediator complex, subunit Med7/Med21-like |
| PFam | PF05983 | Mediator complex, subunit Med7 |
| Superfamily | SSF140718 | Mediator complex, subunit Med7/Med21-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 35557691 | Mediator Complex of the Malaria Parasite Plasmodium falciparum Associates withEvolutionarily Novel Subunits. | Iyer UB, Park JE, ..., Featherstone M | 10.1021/acsomega.2c00368 |
| 28213434 | Malaria during Pregnancy | Fried M, Duffy PE | 10.1101/cshperspect.a025551 |
| 22377631 | Role of Mediator in regulating Pol II elongation and nucleosome displacement inSaccharomyces cerevisiae | Kremer SB, Kim S, ..., Gross DS | 10.1534/genetics.111.135806 |