PF3D7_0822200

Genome location: Pf3D7_08_v3:982,546..987,696(+)

Genome classification: Core

Function and Localization

Product Description: phosphorylated CTD interacting factor 1 WW domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 8

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.38	0.82
Trophozoite	expressed	0.35	0.81
Schizont	possibly expressed	0.10	0.95
Gametocyte	not expressed	0.76	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0822200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.673 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0708500)

Modification: Disrupted | RMgm-2209

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4W8

"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=1.11) with 6IRY (Global RMSD=1.57)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533207

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	77	47	97
disruptive	72	307	163	328
missense	41	259	142	272

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	27	161	50	105
disruptive	147	599	251	440
missense	77	499	196	309

PlasmoDB Total SNPs: 222

Non-coding: 57 | Synonymous: 106 | Nonsynonymous: 59 | Stop Codon: 0

Protein Information

Protein Length: 1510 | Molecular Weight (kDa): 186.588

UniProt ID(s): C0H4W8

PDB ID(s): None

Isoelectric Point: 9.94

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR022035	PCIF1, WW domain
InterPro	IPR039881	mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase PCIF1-like
PFam	PF12237	PCIF1, WW domain
Superfamily	N/A	N/A