PF3D7_0822400

Genome location: Pf3D7_08_v3:989,973..992,608(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	not expressed	0.14	0.92
Schizont	not expressed	0.06	0.96
Gametocyte	not expressed	1.20	0.43

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0822400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -3.036 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0708200)

Relative Growth Rate: 0.94 ± 0.06
Confidence: 7.13

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0708200)

Modification: Disrupted | RMgm-2207

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4W9

"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=0.05) with 6QE6 (Global RMSD=21.39)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532600

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	27	17	23
disruptive	14	47	30	71
missense	13	46	29	61

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	53	21	32
disruptive	22	104	64	115
missense	19	86	53	83

PlasmoDB Total SNPs: 117

Non-coding: 97 | Synonymous: 7 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 486 | Molecular Weight (kDa): 58.407

UniProt ID(s): C0H4W9

PDB ID(s): None

Isoelectric Point: 7.17

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A