PF3D7_0822500 (DLC1)

Genome location: Pf3D7_08_v3:992,633..994,306(-)

Genome classification: Core

Function and Localization

Product Description: dynein light chain 1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Function	GO:0003774	cytoskeletal motor activity
Function	GO:0005515	protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	possibly expressed	0.01	0.99
Schizont	not expressed	0.01	0.99
Gametocyte	expressed	0.14	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0822500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.14 | MFS: -2.851 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0708100)

Relative Growth Rate: 1.00 ± 0.11
Confidence: 5.76

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0708100)

Modification: Disrupted | RMgm-2206

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB59

"Best" AlphaFill ligand hit: FTT (3-hydroxy-tetradecanoic acid, Local RMSD=0.17) with 3FXI (Global RMSD=3.12)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103843

Most Similar Human Ortholog: G3V424

TM-align score: 0.93 | RMSD: 1.29

Seq Identity: 0.45 | Length: 137 / 199

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000119661	dynein axonemal light chain 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	7	10	13
disruptive	1	14	8	22
missense	1	14	8	20

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	19	11	16
disruptive	1	39	13	47
missense	1	28	9	33

PlasmoDB Total SNPs: 150

Non-coding: 137 | Synonymous: 5 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 199 | Molecular Weight (kDa): 23.105

UniProt ID(s): Q2TFW3, Q8IB59

PDB ID(s): None

Isoelectric Point: 8.59

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF52058	N/A