Genome location: Pf3D7_08_v3:996,626..1,000,388(+)
Genome classification: Core
Product Description: protein transport protein SEC23
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030127 | COPII vesicle coat |
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0070971 | endoplasmic reticulum exit site |
| Component | GO:0005634 | nucleus |
| Function | GO:0005096 | GTPase activator activity |
| Process | GO:0090110 | COPII-coated vesicle cargo loading |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.19 | 0.90 |
| Trophozoite | expressed | 0.14 | 0.90 |
| Schizont | expressed | 0.19 | 0.86 |
| Gametocyte | expressed | 0.09 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0822600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.172 | MFS: -2.889 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0708000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IB60
"Best" AlphaFill ligand hit: GNP (phosphoaminophosphonic acid-guanylate ester, Local RMSD=0.76) with 2QTV (Global RMSD=2.17)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100992
Most Similar Human Ortholog: Q15437
TM-align score: 0.96 | RMSD: 1.86
Seq Identity: 0.48 | Length: 747 / 759
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100934 | Sec23 homolog A, COPII coat complex component |
| ENSG00000101310 | SEC23 homolog B, COPII coat complex component |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 41 | 21 | 58 |
| disruptive | 6 | 7 | 4 | 19 |
| missense | 6 | 7 | 4 | 17 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 20 | 104 | 39 | 42 |
| disruptive | 10 | 23 | 33 | 95 |
| missense | 9 | 20 | 21 | 60 |
PlasmoDB Total SNPs: 181
Non-coding: 147 | Synonymous: 21 | Nonsynonymous: 13 | Stop Codon: 0
Protein Length: 759 | Molecular Weight (kDa): 86.169
UniProt ID(s): Q8IB60
PDB ID(s): None
Isoelectric Point: 6.29
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006895 | Zinc finger, Sec23/Sec24-type |
| InterPro | IPR006896 | Sec23/Sec24, trunk domain |
| InterPro | IPR006900 | Sec23/Sec24, helical domain |
| InterPro | IPR007123 | Gelsolin-like domain |
| InterPro | IPR012990 | Sec23/Sec24 beta-sandwich |
| InterPro | IPR036174 | Zinc finger, Sec23/Sec24-type superfamily |
| InterPro | IPR036175 | Sec23/Sec24 helical domain superfamily |
| InterPro | IPR036180 | Gelsolin-like domain superfamily |
| InterPro | IPR036465 | von Willebrand factor A-like domain superfamily |
| InterPro | IPR037364 | Protein transport protein Sec23 |
| PFam | PF00626 | Gelsolin-like domain |
| PFam | PF04810 | Zinc finger, Sec23/Sec24-type |
| PFam | PF04811 | Sec23/Sec24, trunk domain |
| PFam | PF04815 | Sec23/Sec24, helical domain |
| PFam | PF08033 | Sec23/Sec24 beta-sandwich |
| Superfamily | SSF53300 | von Willebrand factor A-like domain superfamily |
| Superfamily | SSF81811 | Sec23/Sec24 helical domain superfamily |
| Superfamily | SSF81995 | Gelsolin-like domain superfamily |
| Superfamily | SSF82754 | Zinc finger, Sec23/Sec24-type superfamily |
| Superfamily | SSF82919 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12850265 | A putative Sec23 homologue of Plasmodium falciparum is located in Maurer'sclefts. | Wickert H, Rohrbach P, ..., Lanzer M | https://pubmed.ncbi.nlm.nih.gov/12850265/ |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 35640768 | Mechanism of ER stress-mediated ER-phagy by CdTe-QDs in yeast cells | Wei F, Yang A, ..., Duan Y | 10.1016/j.toxlet.2022.05.010 |
| 35727050 | Stage-Specific COPII-Mediated Cargo Selectivity in African Trypanosomes | Sharif M, Bangs JD | 10.1128/msphere.00188-22 |