PF3D7_0822700 (TRP1)

Genome location: Pf3D7_08_v3:1,000,443..1,004,032(-)

Genome classification: Core

Function and Localization

Product Description: thrombospondin-related protein 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0071944	cell periphery
Component	GO:0016020	membrane
Function	GO:0008324	cation transmembrane transporter activity
Process	GO:0044409	entry into host
Process	GO:0035891	exit from host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.17	0.92
Trophozoite	expressed	0.48	0.78
Schizont	expressed	0.13	0.92
Gametocyte	possibly expressed	0.20	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0822700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.017 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0707900)

Modification: Tagged | RMgm-4122

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4X0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533198

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	42	26	36
disruptive	45	110	61	170
missense	36	91	48	149

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	74	29	52
disruptive	76	244	122	264
missense	53	186	100	180

PlasmoDB Total SNPs: 258

Non-coding: 106 | Synonymous: 52 | Nonsynonymous: 100 | Stop Codon: 0

Protein Information

Protein Length: 924 | Molecular Weight (kDa): 111.517

UniProt ID(s): C0H4X0

PDB ID(s): None

Isoelectric Point: 8.86

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily
PFam	N/A	N/A
Superfamily	SSF82895	Thrombospondin type-1 (TSP1) repeat superfamily